Information for patients prescribed Quinsair

Quinsair contains an antibiotic called levofloxacin which helps treat chest infections caused by Pseudomonas aeruginosa in adults with cystic fibrosis (CF). Pseudomonas aeruginosa is a common bacterium that affects patients with CF.#

Your healthcare professional has prescribed Quinsair to help treat your lung infection.

This page is designed to give you some key information about using Quinsair, but please remember to read the Patient Information Leaflet inside the pack before starting your treatment.

The importance of managing chronic lung infections in cystic fibrosis
  • Despite recent advancements in cystic fibrosis care, the use of treatments that target chronic airways infections will continue to be an important part of cystic fibrosis care.*
  • Chronic Pseudomonas aeruginosa airway infection can lead to an inflammatory response and affect the ability of the lungs to function.
  • Chronic lung infections are long-term infections which are difficult to treat.
  • You probably have several medications to help with your CF. However, only inhaled antibiotics are proven to manage chronic Pseudomonas aeruginosa lung infections.
  • If you have chronic Pseudomonas aeruginosa in your lungs it is important to take your inhaled antibiotics because they are specifically designed to manage these infections.
  • You may start to feel better and feel that you no longer need your inhaled antibiotics, however you should not stop taking your inhaled antibiotics unless told to do so by your CF team.
  • If you do not take your inhaled antibiotics you will not be managing your chronic lung infections and this could lead to further respiratory complications.**

In the video below, you will learn more about how CF affects the fluid that lines the airways and lungs. In patients with CF, there is a build-up of mucus in the airways which is thick and sticky.

This traps germs which can lead to an infection. Antibiotics like Quinsair work to treat the germs that cause infection.

Supporting information:

* Bell S et al. The future of cystic fibrosis: a global perspective. Lancet Resp. 2020;8:65-124.
† Lyczak JB et al. Lung Infections Associated with Cystic Fibrosis: Clinical microbiology reviews. Apr. 2002; 15(2):194–222.
‡ NICE guideline [NG78]. Cystic fibrosis: diagnosis and management. 25 October 2017.
** Nichols DP et al. Developing Inhaled Antibiotics in Cystic Fibrosis: Current Challenges and Opportunities. Ann Am Thorac Soc. 2019 May; 16(5): 534–539.

What is Quinsair?
  • Quinsair contains an antibiotic called levofloxacin.
  • It belongs to the group of antibiotics called fluoroquinolones.
What does Quinsair do?
  • Quinsair is an inhaled antibiotic used to manage chronic lung infections caused by Pseudomonas aeruginosa in adults with cystic fibrosis.
Why should I take Quinsair?
  • If the infection is not properly treated it will continue to damage the lungs, causing further problems with breathing.
  • You should take Quinsair as prescribed by your healthcare professional, until they tell you to stop. You should not stop using Quinsair without first talking your doctor.
When should Quinsair be taken?
  • You should take Quinsair twice a day, with doses taken as close to 12 hours apart as possible.
  • Inhaling Quinsair at the same time each day will help you remember when to take your medicine.
  • Each course is to be taken for 28 days. You then have 28 days without taking Quinsair, before starting another 28-day treatment cycle.
  • You should keep taking Quinsair in the way your doctor has told you, until they tell you to stop.
How should I take Quinsair?
  • Quinsair should be inhaled twice daily (one ampoule in the morning and one in the evening).
  • Quinsair is designed to be administered using the Zirela® Nebuliser Handset operated with an eBase Controller.*
  • The Zirela® Nebuliser Handset is provided in each box of Quinsair. This should be connected to either an eBase Controller or an eFlow® rapid Nebuliser System.
  • For more information on how to take Quinsair, please view our patient videos: ‘Preparing your NEBULISER SYSTEM’ and ‘Using your NEBULISER SYSTEM’ which can be found here.
  • Filters pads can also be used in a filter/valve set.
  • Filter pads prevent inhaled medication escaping when you exhale, protecting members of your family or people you live with.
  • They can also stop sticky antibiotic residue getting on your furniture and surfaces.

Supporting information:

* Quinsair is designed to be administered using the Zirela® Nebuliser Handset operated with an eBase Controller. Further information on the nebuliser and controller are available at (accessed October 2020).
† Daniels et al. CF Trust, Inhaled therapy for people with cystic fibrosis Factsheet – May 2016.

How long does it take to inhale each dose of Quinsair?
  • It should take about 5 minutes to inhale each dose of Quinsair using the Zirela® Nebuliser Handset provided.
How should I store Quinsair?
  • Quinsair does not require any special temperature storage conditions, so you do not need to keep it in a fridge.
  • You should ensure the plastic ampoules are kept in the original foil packaging, in order to protect it from light.
What should I do if I miss a dose?
  • If you forget a dose, take it as soon as you remember as long as there is an 8-hour interval before inhaling the next dose.
  • However, if it is less than 8 hours until your next dose, skip the missed dose. Do not inhale the contents of more than one ampoule to make up for a missed dose.
Does my Zirela® Nebuliser Handset need cleaning?
  • Yes, it will need cleaning and disinfecting after each use, please refer to the instructions provided with your handset for more information.
  • Or alternatively watch part 3 of our patient videos ‘Looking after your QUINSAIR SYSTEM’ which can be found here.
What are the possible side effects?
  • When you start taking Quinsair you might get an unpleasant taste in your mouth which you’re not used to, but as you continue to take Quinsair, over time, the taste difference should become less noticeable.* Your CF Team may be able to suggest ways to help you manage getting used to the taste of Quinsair.
  • If you would like information about other potential side effects, please see the patient information leaflet which is provided with your Quinsair, an online version of this can be found here.

Supporting information:

* Elborn JS et al. Safety and efficacy of prolonged levofloxacin inhalation solution (APT-1026) treatment for cystic fibrosis and chronic Pseudomonas aeruginosa airway infection. J Cyst Fibros 2016;15:634-640.

Can my medicine be delivered to me?
  • In the UK, it may be possible for you to receive Quinsair via a homecare delivery service, please ask your CF Team for more details.
  • Watch the videos to learn about the correct inhalation technique for when you use Quinsair.




  • Remember you should always ask a member of your CF team if you have any questions about your CF or medication(s).

▼ This medicine is subject to additional monitoring. This will allow quick identification of new safety information. You can help by reporting any side effects you may get. See for how to report side effects in the UK or for Ireland.

Always take your Quinsair treatment as prescribed by your healthcare professional.
If you stop taking Quinsair for any reason, you should tell your doctor as soon as possible.
Remember, you should always ask a member of your CF team if you have any questions
about your CF or your medication(s).


Supporting information: Quinsair® Patient Information Leaflet, Chiesi Limited.
# UK Cystic Fibrosis Registry Annual Data Report 2019, Published August 2020.

IE-CF-2000140 | Nov 2020